Process Heat-Sensitive Pharmaceuticals Without Product Degradation


Process heat-sensitive pharmaceuticals without product degradation


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Constantly evolving products and manufacturing methods are creating new challenges for the pharmaceutical industry. Thermally unstable APIs and bio products can degrade during conventional evaporation and distillation, especially in batch operations. Artisan’s thin/wiped-film, short-residence–time technology is ideally suited for heat-sensitive, viscous materials and liquids that foul, foam or contain solids.

Our technology minimizes temperature exposure and entrainment, improving product purity and yield. And our rugged equipment can process materials with viscosities up to 1 million centipoise. Our experience in recovering, evaporating, stripping, and drying has helped nearly all the world’s leading companies advance and optimize their production methods.

Our extensive experience includes the following pharmaceutical separations:
  • Concentration, drying and recovery of APIs, intermediates and nutraceuticals
  • Solvent recovery for kilo lab and prep chromatography operation
  • Solvent management for Simulated Moving Bed (SMB) chromatography
  • Creating free flowing powders
  • Recovering heat sensitive API’s, intermediate or fine chemicals from solvents


Problem Many compounds are produced in dilute solutions of solvent or are purified in mobile solvent streams, as in the case of chromatography. Heat sensitive, biologically active or intermediate structures within solvent laden, foaming, and/or fouling solutions are challenging mixtures for the recovery of valuable pharmaceutical or fine chemical molecules. Heat sensitivity presents a critical problem because elevated temperatures and exposure time must be controlled to preserve molecular integrity. Solutions with difficult compositions may foul heat transfer surfaces or form disruptive foams that inhibit the process. If heat transfer surfaces foul, throughput is reduced. Two 5 ft² Rototherms® recovering solvent from an SMB process

Solution Rototherm®, Artisan’s horizontal processor overcomes the problems of fouling, foaming, heat sensitivity, solvent content, etc. It allows concentrating and isolating the important ingredient quickly, often in seconds, in a single step. The process can be turned down to accommodate variable processing rates. The process is scalable to any capacity, and active compound efficacy can be demonstrated easily at small volumes and very low concentrations. The combination of vacuum operation and short residence time prevents product degradation. The unique rotor in Rototherm processor allows for efficient self-cleaning of the internal heat transfer surfaces. The highly turbulent thin-film at the heated surface enables heat flux rates of 10,000 to 50,000 BTU/hr-ft². Many feed and processing strategies can be employed to optimize the operation.